Details for Lore Eggermont

Researchgroup Biochemistry and Glycobiology
Function Former member
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Role of nucleocytoplasmic lectins in epigenetic processes in plants.

Nucleocytoplasmic lectins are carbohydrate-binding proteins expressed in the nucleus and the cytoplasm of the plant upon exposure to stress situations like drought, high salt, hormone treatment, pathogen attack or insect herbivory. Therefore it is suggested that these lectins play an important role in the stress physiology of the plant cell. The Nicotiana tabacum agglutinin (abbreviated as Nictaba), a nucleocytoplasmic lectin, belongs to the family of the Nictaba-like lectins and was originally purified from tobacco leaves. Recent research showed an O-GlcNAc dependent interaction of this lectin with histones, so it is proposed that Nictaba plays a signaling role in response to stress by interacting with O-GlcNAcylated proteins (such as e.g. histones) in the plant cell nucleus. We want to study the involvement of nucleocytoplasmic plant lectins in epigenetic control of gene expression in the model organism Arabidopsis thaliana.